Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Answer:Muscle cells are able to produce ATP with oxygen, which is called aerobic respiration, or without oxygen, an anaerobic process called anaerobic glycolysis or fermentation. The process in which ATP is made is dependent on the availability of oxygen (see the Cellular Respiration concepts).
Explanation:
Type of neuron that receives messages from the environment is a sensory neuron ie it receives messages from the 5 senses which are used by man to investigate the environment.
Answer:
the components
Explanation:
when talking about the chemical composition is the same thing as saying the chemical components
The question is asking to choose among the following choices that states the length of time that an organism expected to live, and base on my research and further investigation, I would say that the answer would be A. life span. I hope you are satisfied with my answer and feel free to ask for more
