Question

What effect does histone acetylation have on transcription? Group of answer choices Extremely decrease expression Moderately decrease expression No change in expression Measurably increase expression Either increase or decrease expression

Answer 1

Answer:

Measurably increase expression  

Explanation:

Acetylation of histones, or more precisely their amino acids lysine, causes their positive charge to be neutralized, and weakening of the interaction of the histone tail with negatively charged local DNA induces local opening of chromatin structures. Thus, local DNA is exposed, increasing access to transcription factors and promoting significant increases in gene transcription.

In other words, histone acetylation results in the decompression of chromatin, which measurably increases expression.