Question

Suppose that an unusually high degree of aurora kinase activity is observed in the cervix. What could we reasonably conclude about C5M treatment efficacy across all cervical cancer cell lines, using this new information and the data within the passage

Answer 1

Answer:

The division of cervical cancer cells will be inhibited  

Explanation:

Aurora kinases are a type of serine/threonine kinase enzymes that play critical functions during cell proliferation, and they are recognized to be potential targets in cancer therapy. The benzo[e]pyridoindole (C5M) agent is a hydrosoluble inhibitor of aurora kinases capable of inhibiting cell proliferation. C5M induces mitotic arrest by faulty (no separation) of the sister chromatids during cell division, thereby eventually leading to polyploidy and finally triggering cell death. It has been shown that C5M acts to prevent the entry in mitosis by inhibiting histone 3 (H3) phosphorylation of aurora kinases.