Answer: D.
Explanation: At the time the national gov was quite weak and the individual states were basically their own governments. They ruled themselves and the national government could not force the states to do anything because the states held more power than Congress did.
B. India had many spices China had silk and there had also been many port cities in Africa so ships could get to Asia.
The answer is C. As new colonists and explorers discovered the Americas, they also brought disease. This heavily impacted the American Indians as a majority of their population suffered from epidemics.