1513: Jorge Álvares is the first European to land in China at Tamão in the Zhujiang (Pearl River) estuary. 1516-17: Rafael Perestrello, a cousin of Christopher Columbus, leads a small Portuguese trade mission to Canton (Guangzhou), then under the Ming Dynasty.
There are several ways in which the growth of Alexander’s empire spread Greek culture, but the most important way was that culture was imposed wherever he went.