Explanation: The reduction of mature red blood cells which results from this decreases the capacity of the blood to carry oxygen; the cells therefore remain in a large immature form known as a megaloblast. As this occurs over time, it causes the folate deficiency condition called macrocytic anemia, or megaloblastic anemia.
There's another type of anemia that clinically looks like folate-related anemia due to the enlargement of red blood cells and this is called pernicious anemia. It occurs as a result of insufficient vitamin B-12 intake.
B. horses evolved to have hooves C. genetic mutations are the genetics behind adaptations D. selection is the basis for evolution E. I'm not sure about the willful part but hooves would be considered an adaptation to the environment <span />