Question

In this activity, you will explore how DNA microarrays are being used as a tool for studying-and possibly treating--cancer 1 2 3 4 567 89 10 11 12 13 14 15 16 The data shown here were obtained from a DNA microarray study of gene expression patterns in 16 cancer patients. Although data for many more genes were obtained from the DNA microarray, only 12 specific genes of interest are shown. gene F gene T gene 2 gene P gene X gene U gene B gene H gene S ene K gene G gene Q
The data in the chart are color-coded as indicated by the key that appears below the chart. Red represents high relative gene expression and blue represents low relative gene expression.
Dala frem T R edub ㎡ ' Molecular Clessiicafor, of Cancer: Class Discovery rd Clos Prodcin by Gone Expresson Monikring Science 2BB 531 537 1999)
Which of the following conclusions do the data support? Select all that apply
3 -2.5 21.5 1 0.5 0 0.5 1.5 2 2.5 3 Normalized Expression low high
A) Gene K is more highly expressed in cells from patients in Group I than in cells from patients in Group ll.
B) For some genes, there is variation in the amount of mRNA present, even among patients in the same group
C) Cells from patients in Group I carry different sets of genes than cells from patients in Group II.
D) A different set of genes is transcribed in cells from patients in Group ' oompared to cells from patients in Group II
E) If you were given microarray data from the cells of a new patient belonging to either Group I or Group II, you would probably be able to tell which group the patient belongs to.

Answer 1

Microarray data attached

Answer:

B, D, E are consistent with the data in the microarray

Explanation:

A) False, if you look at the microarray graph, Gene K is red on the right side of the graph (where patients in group II are) and generally more blue on the left side where group I patients are, meaning it is less expressed

B) This is true, look for example at gene F, individual 3 expresses it strongly, whereas individuals 6 and 7 are quite low.

C) No - microarray data looks at the expression of genes, not the genes themselves.

D) Yes, you can see that generally, genes B-Q are highly expressed in group II patients but not group I. In contrast, genes F-U are not expressed in group II but more expressed in group I.

E) Yes, although the data is not always consistent, there are clear patterns in group II patients not present in group I.