Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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Answer: Not likely
Explanation:
Hurricanes can be devastating if they make landfall in an area and even if they do not, can cause excessive rainfall that can lead to flooding in other areas. One of such areas is Maryland.
Even though Maryland has seen its fair share of effects from hurricanes, tropical storms and tropical depressions, there has not been a single storm making landfall at hurricane intensity in Maryland since the mid twentieth century. Hurricane Agnes for instance, caused the deaths of 19 people due to the floods it caused.
Answer:
Evaporation and Transpiration
Explanation:
Evaporation is the process in which water from bodies of water vaporizes and enters the atmosphere while transpiration is the process in which water from plants evaporates into the atmosphere.