The answer would be B as penicillin is derived from Penicillium fungi.
Chinese hamster ovary cell production of recombinant tissue‐type plasminogen activator (t‐PA) was increased by amplification of cotransfected dihydrofolate reeducates cDNA using stepwise adaptation to increasing methotrexate (MTX) concentrations. The highest producing clones were isolated at 5 μM MTX and yielded 26,000 U/106 cells/day t‐PA (43 μg/106 cells/day). Above 25 μM MTX, cell specific t‐PA production rates became increasingly variable and the cDNA copynumbers decreased. No apparent correlation between the cell specific t‐PA production rate and the growth rate was observed upon sub cloning of the amplified cells. When MTX selection was removed, the t‐PA production rate decreased up to tenfold within 40 days; this was accompanied by an up to 60% drop in cDNA copynumber. Subclones isolated after 108 days of culture in the absence of MTX were, on average, sixfold more stable than their parental cells. In culture without MTX, the maximum stable t‐PA production rate obtained (over 250 days) was 7000 ± 750 U/106cells/day (∼12 μg/106 cells/day), approximately threefold lower than the maximum unstable levels of production reached under selective pressure. Taken together, these results define a wide range of the highest t‐PA expression rates obtained under MTX selection, for which stable expression without selection has not been reported
Answer:
The correct answer will be- red blood cells (RBC)
Explanation:
Malaria has proved endemic to the human species as it has killed the humans in large numbers and it has acted as one of the strongest selective force.
The malaria disease has caused the mutation in the genes in the red blood cells which carries the oxygen to different organs of the body. The mutation in the genes causes the circular shape of red blood cell to sickle-shaped cells which carry less oxygen to the organs.
The change in the shape of red blood cell provides resistance against malaria disease but it becomes a problem where malaria is not a problem.
Thus, red blood cells (RBC) is the correct answer.
Explanation:
Access to a fresh water supply is affected by the following factors.
Climate. Low levels of rainfall and high temperatures lead to water deficits . ...
Geology. Rainfall flows down to the rocks beneath the ground. ...
Pollution. ...
Over-abstraction. ...
Limited infrastructures. ...
Poverty. ...
Politics. ...
Impacts on water insecurity.
A Japanese research team reported that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery of spinal damage.
