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Elis [28]
3 years ago
12

While studying the function of a G protein-coupled receptor you develop a modified GTP molecule that has the same binding capabi

lities as GTP but cannot be hydrolyzed to GDP + Pi. What effect would this molecule have if added to your GPCR signaling pathway?
Biology
1 answer:
laila [671]3 years ago
7 0

<u>Answer:</u>

Effects Include:

Activates secondary messengers such as cAMP which further activates number of hormones like

  • ADH: production of this hormone causes kidneys to retain more water inside body.
  • GHRH: release growth factors and stimulates growth of organism.
  • ACTH: produces fight or flight responses i.e rise in heart beat, rise in Blood pressure etc
  • TSH: Stimulate the synthesis of Thyroid hormone and enhances the metabolism of body. In rare cases causes Goiter without the deficiency of Iodine.
  • LH: Stimulate follicle maturation and formation of ovules in women.
  • Calcitonin: Decreases blood calcium level by deposition calcium in bones. This effect weakens the muscles.
  • Glucagon: Stimulates glycogen breakdown from liver and muscles and many more effects.

<u>Explanation:</u>

Background Knowledge:

GPCR (G Protien coupled receptors) are present inside plasma membrane in huge amount. As name suggest that these receptors are coupled with G proteins during their inactive state present inside of the cell. During their Inactive state these G proteins are bounded with GDP molecule.

Upon receiving signal molecules from outside of cell alters the shape of GPCR. These receptors also triggers change in G Protein, as a result of this GTP get attached with them. This protein further activates reaction cascades inside of the cell.

What happen if GTP cannot be hydrolyzed to GDP + Pi?

If GTP cannot hydrolyzed in to GDP + Pi than, it cannot be able to dissociate from G proteins. Cascade system doesn't stop and produces many effects on body.

Effects Include:

Activates secondary messengers such as cAMP which further activates number of hormones like

  • ADH: production of this hormone causes kidneys to retain more water inside body.
  • GHRH: release growth factors and stimulates growth of organism.
  • ACTH: produces fight or flight responses i.e rise in heart beat, rise in Blood pressure etc
  • TSH: Stimulate the synthesis of Thyroid hormone and enhances the metabolism of body. In rare cases causes Goiter without the deficiency of Iodine.
  • LH: Stimulate follicle maturation and formation of ovules in women.
  • Calcitonin: Decreases blood calcium level by deposition calcium in bones. This effect weakens the muscles.
  • Glucagon: Stimulates glycogen breakdown from liver and muscles and many more effects.
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That question, this incomplete. The full question is:

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Explanation:

An independent variable is one that exerts an influence within the experiment and can be measured, acting on other elements to promote the observation of a result. As the experiment seeks to observe the influence of humidity on the height of the tree, we can say that humidity is the independent variable.

Dependent variable is that which is influenced by the independent variable to generate a result that can be observed, can also be measured. As the experiment wishes to analyze how the height of the trees was affected by the level of humidity, we can say that the height of the trees is the dependent variable.

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