Activates secondary messengers such as cAMP which further activates number of hormones like
ADH: production of this hormone causes kidneys to retain more water inside body.
GHRH: release growth factors and stimulates growth of organism.
ACTH: produces fight or flight responses i.e rise in heart beat, rise in Blood pressure etc
TSH: Stimulate the synthesis of Thyroid hormone and enhances the metabolism of body. In rare cases causes Goiter without the deficiency of Iodine.
LH: Stimulate follicle maturation and formation of ovules in women.
Calcitonin: Decreases blood calcium level by deposition calcium in bones. This effect weakens the muscles.
Glucagon: Stimulates glycogen breakdown from liver and muscles and many more effects.
<u>Explanation:</u>
Background Knowledge:
GPCR (G Protien coupled receptors) are present inside plasma membrane in huge amount. As name suggest that these receptors are coupled with G proteins during their inactive state present inside of the cell. During their Inactive state these G proteins are bounded with GDP molecule.
Upon receiving signal molecules from outside of cell alters the shape of GPCR. These receptors also triggers change in G Protein, as a result of this GTP get attached with them. This protein further activates reaction cascades inside of the cell.
What happen if GTP cannot be hydrolyzed to GDP + Pi?
If GTP cannot hydrolyzed in to GDP + Pi than, it cannot be able to dissociate from G proteins. Cascade system doesn't stop and produces many effects on body.
Effects Include:
Activates secondary messengers such as cAMP which further activates number of hormones like
ADH: production of this hormone causes kidneys to retain more water inside body.
GHRH: release growth factors and stimulates growth of organism.
ACTH: produces fight or flight responses i.e rise in heart beat, rise in Blood pressure etc
TSH: Stimulate the synthesis of Thyroid hormone and enhances the metabolism of body. In rare cases causes Goiter without the deficiency of Iodine.
LH: Stimulate follicle maturation and formation of ovules in women.
Calcitonin: Decreases blood calcium level by deposition calcium in bones. This effect weakens the muscles.
Glucagon: Stimulates glycogen breakdown from liver and muscles and many more effects.
They would be a damage of cells because homeostasis regulate the internal body environment so as to maintain a steady state to provide optimum conditions for normal and efficient functioning of the body cells.
