Scientists have found that extracellular matrix component may induce specific gene expression in the embryonic tissues such as the liver and testes. For this to happen, there must be a direct communication between the extracellular matrix and the developing cells. The Integrins of transmembrane protein would most likely be involved in this kind of induction.
Integrins are the main principal receptors used by the cells of animal to bind to the matrix of extracellular. They are heterodimers and they function as transmembrane linkers between the actin cytoskeleton and the extracellular matrix. A cell can regulate the sticky activity of its integrins from within.
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