accumulations of genetic mutations over time.
Genetic and epigenetic changes compound over time to cause cancer. While aging and chronic inflammation are the major causes of epigenetic changes, carcinogenic substances, UV radiation, and other conditions can also cause genetic changes. Our prior exposure levels and life history are reflected in the accumulation and patterns of changes in normal cells. The majority of accumulated changes are regarded as passengers, although they are linked to cancer drivers as they accumulate. Although only hypothesized for genetic changes, this has been demonstrated for aberrant DNA methylation. However, modern technology has made it possible to assess uncommon point mutations, and research has revealed that the rates of their accumulation do actually correspond with cancer risk.
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Covalent Bonds: A Hydrogen Example. A covalent bond is a chemical bond that comes from the sharing of one or more electron pairs between two atoms. Hydrogen is an example of an extremely simple covalent compound. A hydrogen example.
