Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
The correct option is C.
Obligate anaerobes are micro organisms that are poisoned and killed when exposed to the normal atmospheric oxygen concentration. These organisms can only survive in the absences of oxygen, therefore, they carry out only anaerobic form of respiration in order to obtain the energy that they need. <span />
Answer: Typed 2 diabetes; because plasma glucose molecules are retained in the blood and not able to enter the cells.
Explanation:
He suffered from type 2 diabetes because, the ketoacidosis was due to breakdown of fats in the liver due to low glucose in the cells, while the hypoglycemia was due to retention of plasma glucose in the blood instead of entering the cells.
Answer:
Iodine
Explanation:
This is a trace element needed for the synthesis of the two thyroid hormone ; T4- thyroxine and T3-triiodothyronine. Four iodine molecules are added in T4 synthesis, and three for T3 synthesis. Generally T4 is the major hormone produced, but biologically transformed into active form T3.
Iodine majorly and selenium are the two trace elements needed for thyroid hormones synthesis. Therefore required amount of iodine is important in daily diet. iIn adequate supply of this leads to under production of iodine called hypothyroidism. poor brain development ( especially in kids),and goiter.
Sea foods . eggs, poultry seaweeds are rich sources of iodine.
Conversely, when excessive amount is present in the blood, autoimmune thyroid diseases can occur,including cancer developments in the thyroid gland due to hyper cell activities.
I believe that the correct answer is A
