Methotrexate inhibits the synthesis of DNA, RNA, and protein synthesis of the cells in the experiment.
Explanation:
Methotrexate competitively inhibits the enzyme dihydrofolate reductase (DHFR) which is involved in the synthesis of tetrahydrofolate from the inactive dihydrofolate. The methotrexate blocks the enzyme by binding to its active site thereby preventing further reaction of the dihydrofolate reductase enzyme and dihydrofolate. Tetrahydrofolate is a useful material for the de novo synthesis of thymidine, a nucleoside. And without thymidine, DNA synthesis is hindered. Methotrexate therefore inhibits the synthesis of DNA, RNA, thymidylates and of course protein synthesis.
Anaerobic respiration (both glycolysis and fermentation) takes place in the fluid portion of the cytoplasm whereas the bulk of the energy yield of aerobic respiration takes place in the mitochondria.
A psychological disorder or a mental disorder is compose of behavioral and psychological symptoms impacting on areas of one's life causing further problems. When a psychiatrist like Dylan works on the causes of the disorder such as chemical imbalances, he is now working on the Biological perspective of the treatment.
