you answered your own question
Some difficulties was a lack of control with diseases. People did not know much about medicine and germs so diseases killed off a lot of people. Captain Jhon smith in 1608 saved virginia from collapse.
Answer:
Humanism. During the 14th century, a cultural movement called humanism began to gain momentum in Italy. Among its many principles, humanism promoted the idea that man was the center of his own universe, and people should embrace human achievements in education, classical arts, literature and science.
Answer:
With war comes devastation, depression, deprivation and death.
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I think the answer is <span>D) Its location caused the development of cosmopolitan cities.</span>