Ans.
HD (Huntington's disease) is a genetic neurological disorder that occurs due to damage and death of brain cells. it is caused by an autosomal dominant mutation in HTT (huntingtin) gene, having a trinucleotide repeat section that makes HTT protein.
The mutation leads to an increase in this nucleotide repeat count, associated with formation of altered or mutated huntingtin protein. These altered proteins show deleterious affect on brain cells and result in Huntington's disease.
Thus, the correct answer is 'option A). a mutated gene.'
Answer:
<em>B. Different crops could be grown on the same land.
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Explanation:
Crop rotation is the process of growing different plants in the same land according to the season. Various kinds of plants require various sorts of supplements from the soil.
Changing crops on a regular basis enables the land to stay rich in nutrients, since not the majority of similar nutrients are being utilized each season. Crop rotation likewise fights against the powers of soil erosion. It also helps to improve the stability of the soil by shifting back and forth between harvests with profound roots and those with shallow roots.
Answer:
A. The chromatin near cis-regulatory sequences will be more closed and there will be less transcription.
Explanation:
In the presence of histones, the cis-regulatory sequences of DNA like promoter, enhancers etc. are not exposed. The function of the histone acetyltransferases (HATS) is to cause chromosome decondensation i.e. removal of histones from the DNA so that transcription of the DNA could occur. Histone acetyltransferases (HATS) cause acetylation of lysine amino acid of the histone proteins. Acetyl group is negatively charged so the acetylation of histone proteins leads to the removal of their positive charge which ultimately leads to the decrease in the interaction between N terminal of histones and negatively charged phosphate group of the DNA molecule. As soon as histones are removed from the DNA where cis-regulatory sequences are located, the DNA becomes accessible for transcription.
But here a drug has been added which blocks the activity of histone acetyltransferases (HATS) in cancer cells. So it is quite evident that in these cells, histones will not get removed from the cis-regulatory sequences of DNA so the DNA will be more closer or tightly packed as a result of which less transcription will occur.
