Mercutio said "<span>A plague o' both your houses!" three times from the time he was stabbed by Tybalt until the time he was sent to a house to see to his deadly wound.
Mercutio cursed the houses of the Capulets and Montague. For the quarrel of these two houses brought about his untimely death.</span>
In Act 3, Scene 1 of "Romeo and Juliet", while Mercutio is dying he curses both families, the Montague and the Capulets. He says "A plague o' both your houses", also transcribed as "A pox on both your houses". Mercutio curses these families because he thinks he has been mortally wounded as a consequence of their feud. Sowith those remarks, "A plague o'both your houses", Mercutio is cursing both Romeo's and Tybalt's families, the Montague and the Capulets.
