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slamgirl [31]
3 years ago
7

Which one of the following enzymes of nucleotide metabolism is correctly paired with its pharmacologic inhibitor?

Biology
1 answer:
aivan3 [116]3 years ago
7 0

Answer:

A. Dihydrofolate reductase—methotrexate

Explanation:

Dihydrofolate reductase is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid. Methotrexateis its inhibitor. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme.

Since folateis necassary for rapid dividing cells, such as cancer cells, methotrexate can be used as anticancer drug that inhibits DHFR.

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