Correct answer:
"All of these are equally affected."
When in Alzheimer's disease, all of the working memory is in peril. In early stages of Alzheimer's disease, all of these functions start to have problems. Phonological loop is basically the capacity to memorise speech or information in it. Central executive is the ability to switch attention from one activity to another that is needing more attention. The visuospatial sketch pad is the ability to handle visual and spatial information being able to judge distances for example. All of these are part o the working memory and are affected from the early stages of Alzheimer's disease.
Proteins that are functionally less important for the survival of an organism generally evolve faster than more important proteins.
Proteins serve as the building blocks for all of life's essential processes. The proteins evolve along with the genes that create them, adding new functionality or features that may potentially result in the development of new species.
The mutation of amino acid-coding nucleotides and the stabilization of novel variations in the population are the two phases required for protein evolution.
The stability of a protein's folded structure, how well it prevents aggregation, and how well it is chaperoned all affect how quickly it evolves. According to the studies, the degree of a protein's expression has a greater influence on its evolutionary rate than does the protein's functional significance.
To learn more about protein and mutation here,
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coffee beans is a seed of coffea plant and source for coffee