It is supported by evidence from a wide variety of scientific disciplines, including genetics, which shows that different species have similarities in their DNA. There is also evidence supporting the Theory of Evolution in paleontology and geology.
The correct response in this case would be denature, the enzyme will no longer be able to catalyze the reaction if there is an abnormally high change in the pH or the temperature.
#1 water
#2 protein
#3 carbohydrates
#4 animals