Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
Phoebus Levene was the one who proposed <span>the polynucleotide model stating that dna and rna were composed</span>
The number of amino acids that will be in the polypeptide chain produced by the normal DNA or MRNA sequence is usually 30 amino acids. Although the number of amino acids depends on the function of the generated DNA or RNA. The types of amino acids also differ depending on the function.
One way to reduce water consumption on farms is to use drip irrigation. Drip irrigation is a way of watering the plants in the farm directly to their roots. By this less water are consumed and you are sure that the plant really received the amount of water that they need.
Answer
In the presence of oxygen two energy products are produced, these are:
1. ATP
2. NADH2
One NADH2 produce three ATP.
Conclusion:
so in the presence of oxygen the energy rich compound which is produced during glycolysis is NADH2.
