Such changes would occur mostly likely near or in the active binding site of the enzyme.
Because the drugs used are competitive inhibitors of the <span>HIV reverse transcriptase enzyme, it means that they connect directly to the active binding site of this enzyme not allowing it to preform its function. If the mutations impede this drugs to work, it is probably because they alter the active binding site of the enzyme, not allowing the drug to bind and have its competitive behaviour permitting the enzyme to work normally. </span><span /><span>
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'RNA is transcribed and translated in the cytoplasm', 'transcription produces an mRNA ready for translation' and 'RNA is proofread for errors' occur in prokaryotes, whereas '5′ cap, 3' poly-(A) tail and RNA splicing' occur in eukaryotes.
The prokaryotic cells (e.g., bacterial cells) do not contain cell nuclei, thereby the messenger RNA (mRNA) must be transcribed and translated in the cytoplasm.
During prokaryotic transcription, the RNA transcript is proofread for errors. In bacteria, DNA polymerases proofread the transcript by using their 3’ → 5’ exonuclease activity.
In eukaryotic cells, RNA processing consists of several mechanisms:
- A 7-methylguanosine cap (5′ cap) is added to the 5′ end of the precursor messenger RNA (pre-mRNA).
- A 3' poly-Adenine (A) tail is added to the 3' end of the pre-mRNA.
- Both the 5′ cap and 3' poly-(A) tail protect the RNA transcript from its degradation by exonucleases.
- Eukaryotic RNA splicing consists of the removal of non-coding regions called 'introns' and subsequent splicing of the protein-coding regions called 'exons'.
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<span>B. The have been Earth's only hominine for the last 24,000 years.
After the unknown eradication of the Homo Neanderthals, Homo Sapiens became the only homonine for the last 24,000 years. That is to say, that modern humans are the result of the evolution of homo sapiens to homo sapiens sapiens.</span>
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So when the first animals moved onto land, they had to trade their fins for limbs, and their gills for lungs, the better to adapt to their new terrestrial environment
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