Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
Answer:
a. deterioration of neurons that produce the neurotransmitter acetylcholine.
Explanation:
Alzheimer's disease -
It is a disease associated with memory , it is a type of dementia .
The initial stages of the disease is the remember new things , the day to day task becomes very difficult with time .
During this disease the neurons get deteriorated day by day , which are responsible to produce the acetylcholine .
Hence , the correct statement about Alzheimer's disease is ( a ) .
<span>Mitosis, simply put, is the division of the nucleus of a cell. It is the phase in the cycle of a cell in which the two chromosomes in a cell divide and separate in a nucleus of their own. These chromosomes are completely identical. As a result of mitosis, two identical cells are formed and are known as daughter cells. This process copies and transfers DNA into both the cells that are formed as a result of Mitosis.</span>
The answer is D. This is an exmaple of incomplete dominance. Red and blue make purple. Because there is no purple alleles, C is false. Because there you can only have 2 alleles total B is false. A is false because having two red alleles makes a red flower.
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Answer:</h2>
<h3>In a fat molecule, the fatty acids are attached to each of the three carbons of the glycerol molecule with an ester bond through the oxygen atom. During the ester bond formation, three molecules are released. Since fats consist of three fatty acids and a glycerol, they are also called triacylglycerols or triglycerides.</h3>
