The cell is in a hypertonic solution. Because there are more solutes outside the cell, the water will flow outside the cell in order to restore equilibrium.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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<span>3. Cells use glucose to store large amounts of energy for long period of time.
In contrast, ATP is used to </span>store smaller amounts of energy that will be used in the next few seconds.<span>
A glucose molecule can store more than 90 times the energy of a ATP molecules.
4. The fact that the potted plant is in air tight jar affect the process of photosynthesis. The plant is airtight jar which means that the plant is not able to breath and run out of CO2 to produce sugars. So t</span><span>he plant wouldn't be able to complete photosynthesis.</span>
This is a neutral atom of chlorine.
