I think the answer is C) Knots are related to the global coordinate system.
Improper temperature control is one of the primary causes of illness or diseases as if the temperature is not set right, it could make bacteria grow or expand which is potentially harmful especially if they are to consume food-- if you food is contaminated with harmful bacteria because of improper temperature control, it could cause the food to be contaminated or spoiled, when consumed, it could led the person to have food poisoning.
You can't have a carrier with a dominant pedigree because other wise than individual or organism would be afflicted by the gene and render them incapable of being a carrier. A carrier is an individual/organism that has a normal phenotype (meaning it is not afflicted by said gene) but is carrying the gene that could cause disease or whatever the affect may be. In this case the gene would have to be homozygous recessive to be expressed. Hopefully this helps!