They invaded the land of the native americans, treating them in an unfriendly and violent manner when they arrived. The effects of colonization on the native populations in the New World were mistreatment of the natives, harsh labor for them, and new ideas about religion for the spaniards.
The correct answer is: "public health".
The Sanitation Standard Operating Procedures are applied to food production with the aim of making sure that the manufacturing processes employed do not mean a threaten to human health.
These standard procedures are a prerequisite established in the Hazard analysis and critical control points, or HACCP, a preventive approach introduced with the ultimate goal of achieving food safety, which means that the final food products and their production processes are free of biological, chemical, and physical hazards.
Very abbreviated answer: The Black Death was another name for the plague, this claws caused by rats and lead to death of a large sum of the population.
I would go with the last option.