Competition and predation
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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Answer:
Deep ocean trenches, volcanoes, island arcs, submarine mountain ranges, and fault lines are examples of features that can form along plate tectonic boundaries. Volcanoes are one kind of feature that forms along convergent plate boundaries, where two tectonic plates collide and one moves beneath the other.
Explanation:
Volcanoes at convergent plate boundaries are found all along the Pacific Ocean basin, primarily at the edges of the Pacific, Cocos, and Nazca plates. Trenches mark subduction zones. The Cascades are a chain of volcanoes at a convergent boundary where an oceanic plate is subducting beneath a continental plate.
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Inspection, survey, surveillance.
The most likely conclusion the student will make would be that increasing temperature increases the rate of reaction.
<h3>Effects of temperature on reaction rates</h3>
The rate of reaction of a system is directly proportional to the temperature of the system.
This is because the kinetic energy of the reactant's molecules is increased by increasing the temperature of the system. Thus, reactant molecules collide more and this leads to more reactions.
Thus, increasing the temperature of a system moderately also increases the rate of reaction in the system. Too much increase in temperature, however, can destroy the structures of reactants.
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