The picture shown is the cell membrane made of a phospholipid bilayer and proteins embedded. The phospholipid bilayer is made up of hydrophilic (attracted to water) phosphate heads (D), and hydrophobic (repelled by water) tails (E)
The hydrophobic tails face in the way towards each other, while the heads point outwards towards the cell/extracellular environment.
This is because the hydrophobic tails form a conformation that minimizes their contact with water. So you are least likely to find water at E