I'm not sure about number 1 or number 6, but I know that 3 is nucleic acid and 5 is solution.
Answer:Phosphorylation cascades are similar to a row of dominoes falling down, instead of one domino knocking down the next, a phosphate being added activates the message. In this way, a series of different _(phosphate group) are each _(added ) after another. Inactive protein kinase 1 gets a __(phosphate group_)___ added and now it is active protein kinase 1. Active protein kinase 1 transfers a (phosphate group) and now inactive protein kinase 2 is now ___(active)_____. This continues until the desired (protein ) is activated to cause a cellular response.
Explanation:
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
The objective itself is usually a cylinder containing one or more lenses that are typically made of glass; its function is to collect light from the sample.
Explanation:
A telescope mirror can be made from glass that is somewhat less pure than that used to make a lens, since light does not pass through it.
If you have any questions feel free to ask in the comments - Mark
Also when you have the chance please mark me brainliest.
<span>C.
has strong legs for running
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