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The reason of why Brendon experience immense physical pain
and increased craving upon withdrawal because of physical dependence. Physical
dependence is a physical condition that occurs after a gradual drug withdrawal
in which the drug is being chronically used that upon withdrawal, it causes unpleasant
symptoms, mainly, physical.
There may be some strains of bacteria that are naturally resistant to these antibiotics, or there may be some that mutate to become resistant. This means that as antibiotics are used more and more, those that can be killed using the antibiotics die out, but those that are resistant will remain, and will reproduce. Over time, it will be the resistant species that predominate.