Physical dependence is a physiological condition in which continuous use of a drug makes the brain to adapt and develop tolerance against the effect of the drug, and as a result, the body would require continuous use of that drug to maintain the positive effect the individual gets from using such drugs. A withdrawal from the use of the drug by the individual would bring about uncomfortable and unpleasant withdrawal symptoms. Misuse of drugs such as opioids, amphetamines etc can result in physical dependence.
