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The North American fur trade was an industry and activity related to the acquisition, trade, exchange, and sale of animal furs in North America. Aboriginal peoples in Canada and Native Americans in the United States of various regions traded among themselves in the pre–Columbian Era. Europeans participated in the trade from the time of their arrival in the New World, extending the trade's reach to Europe. The French started trading in the 16th century, the English established trading posts on Hudson Bay in present-day Canada during the 17th century, while the Dutch had trade by the same time in New Netherland. North American fur trade was at its peak of economic importance in the 19th century, and involved the development of elaborate trade networks.
The fur trade became one of the main economic ventures in North America attracting competition among the French, British, Dutch, Spanish, and Russians. Indeed, in the early history of the United States, capitalizing on this trade, and removing the British stranglehold over it, was seen as a major economic objective. Many Native American societies across the continent came to depend on the fur trade as their primary source of income. By the mid-1800s changing fashions in Europe brought about a collapse in fur prices. The American Fur Company and some other companies failed. Many Native communities were plunged into long-term poverty and consequently lost much of the political influence they once had.
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Explanation: A frameshift mutation completely changes the genetic code from the point of the mutation, so the protein made as a result of the mutation would have the incorrect structure and would not function as it should.
I think it's aeration but I'm not 100% sure though.
