Question

If an organism used glycolysis (Embden-Meyerhof-Parnas pathway) but were unable to use fermentation or an electron transport chain, what problem would develop?
A) Glycolysis rates would increase in order to compensate for the lack of ATP produced by the other processes.
B) The cell would run out of glucose and glycolysis would stop.
C) The available NAD+ would be converted to NADH and glycolysis would stop due to the lack of NAD+.
D) The cell will run out of ATP and glycolysis will stop.

Answer 1

Answer is option "C"

Explanation:

• NAD+ is a significant co-compound for hydride move catalysts fundamental to numerous metabolic procedures including glycolysis, pyruvate dehydrogenase complex, the TCA cycle and oxidative phosphorylation. The catalysts utilizing NAD+ in hydride-move are known as dehydrogenases or oxidoreductases, which catalyze the decrease of NAD+ into NADH  
• NADH shaped from glycolysis (by means of the malate-aspartate transport) or the TCA cycle can respond at Complex I, otherwise called the NADH/coenzyme Q reductase in the mitochondrial electron transport chain [28]. Each NADH devoured by the mitochondria brings about the net creation of 3 ATP atoms (Figure 1). The total oxidation of one glucose atom creates 2 NADH reciprocals in cytosol and 8 NADH particles in mitochondria, empowering creation of 30 ATP counterparts from NADH of the aggregate of 36 ATP counterparts got from the entire procedure of catabolizing glucose to CO2 and H2O.
• Hence, the right answer is option C " the available NAD+ would be converted to NADH and glycolysis would stop due to lack of NAD+.