Answer:
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Mast cell release histamine and heparins molecules that are significant in initiating/mediating the inflammatory response. This is why mast cells are highly granulated and are categorized as granulocytes. An example of such a response is when an allergen bind to the IgE of a mast cell inducing secondary communication mechanism inside the cell leading to release of the transmitters.
They both increase because if herbivore increases, then so does the carnivore because of more food to eat.
Answer: about 22.5 million years.