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In this study, we tested the effects of NEAA-deprived diets and checkpoint inhibitor anti-PD-1 and anti-PD-L1 in colon cancer using syngeneic mouse model (Balb/c) bearing tumors of mouse colorectal cancer cell line CT-26. Three diets were tested, including a natural rodent diet Teklad ENVIGO Global 16% Protein Rodent Diet (control 1), a formulated NEAA-complete diet COMPLETE (control 2, using amino acid mix in place of protein), and a formulated NEAA-deprived diet FTN203 (treatment, using amino acid mix in place of protein). Both COMPLETE and FTN203 have the same nutritional structures, contain 17% w/w protein equivalent, and are isocaloric. After tumor size-based randomization, these diets were provided to mice ad libitum throughout the whole test. Each of these diets was used alone or combined with anti-PD-1 antibody (i.p., twice per week for 2 weeks) or anti-PD-L1 antibody (i.v., twice per week for 2 weeks).
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output ang tawag sa bunga ng pagsasama ng salik ng edukasyon
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I don't know I'm terrible at AP history
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The combination of seawater's thermal expansion associated with this warming and the melting of mountain glaciers is predicted to lead to an increase in global sea level of 0.45-0.82 metre (1.4-2.7 feet) by 2100 under the RCP 8.5 emissions scenario. However, the actual rise in sea level could be considerably greater than this.
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