<span>Okay, so we have one homozygous, the prefix "homo" means "same" and we know that the male's genotype is dominate, so with the prefix "same" or "homo" we know the male's genotype must be EE, and TT. We also know that the female's genotype is heterozygous, and knowing that "hetero" means opposite, we know that she has the two opposite types of genes Ee and Tt
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i hope this helps
Answer:
As DNA contain phosphorus in its structure in large amount, therefore, Harshey and Chase labeled DNA with radioactive phosphorus and because protein contains some amino acids which have sulfur so they labeled T2 bacteriophage protein with sulfur.
So after that they infected E.coli bacteria with radioactively labeled phages and after centrifugation, they have found that pellet which contains cells is showing the presence of radioactive phosphorus and supernatant which have T2 phage capsid protein showing the presence of radioactive sulfur.
Therefore by labeling viral protein and viral DNA they found that DNA is the genetic material not protein.
Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
