Question

In the presence of cocaine, the maximal rate of transport (Vmax) is unaffected, but the apparent affinity of the transporter for dopamine is reduced
True/False

Answer 1

Answer:

True

Explanation:

Neurotransmission is modulated by the dopamine transporter. Dopamine transporter leads to activation of protein kinase which in turn reduces the uptake of dopamine. Due to this, the Vmax reduces and the affinity of transporter remains unchanged.  

However, in the presence of cocaine activity of dopamine transporter is inhibited as cocaine and dopamine-binding sites are more or less similar to each other. Dopamine stops blocks the dopamine transporter and reduces the uptake of dopamine. This leads to constant Vmax but reduced affinity of transporter

Hence, the given statement is true