<span>A drug used to treat CML, imatinib, binds to the active site of Abl kinase. Why does this drug work to treat this type of cancer?
</span><span>B) By binding to the active site, the drug prevents the ability of Abl kinase to bind to its substrate.
</span>
Imatinib works against CML by binding close to the ATP binding site of bcr-abl. The binding results to the<span> locking in of the bcr-abl to a closed or self-inhibited conformation and inhibiting the enzyme activity of the protein </span><span>semi-competitively.</span>
Answer:
Option 3. cohesion transpiration is the correct answer.
Explanation:
Plants release water through transpiration while cohesion is responsible for moving more water throughout the xylem. When the water evaporate through the stomata, more water is pulled from roots into stem and eventually reach the leaf this process is called transpiration-cohesion theory. (More explanation in attached Picture)
The correct answer is: b. It is free to bind to another promoter and begin transcription
Transcription is the first step of gene expression in which DNA molecule is copied (transcribed) into RNA (mRNA) by RNA polymerase. The process of transcription is divided into three phases:
1. Initiation
• RNA polymerase with transcriptional factors bind to gene promoter
• RNA polymerase unwinds DNA double helix (transcription bubble is formed)
2. Elongation
• RNA polymerases adds nucleotides complementary to DNA
3. Termination
• RNA polymerase gets to stop codon (transcribes a sequence of DNA known as a terminator)
• Formed complementary RNA strand is released from DNA-RNA complex.
RNA polymerase is also released and can transcribe some other gene by binding to its promotor. RNA polymerase will transcribe just the genes whose products are needed at a particular moment.
