Answer:
Results
We systematically analyze and compare how different modelling methodologies can be used to describe translation. We define various statistically equivalent codon-based simulation algorithms and analyze the importance of the update rule in determining the steady state, an aspect often neglected. Then a novel probabilistic Boolean network (PBN) model is proposed for modelling translation, which enjoys an exact numerical solution. This solution matches those of numerical simulation from other methods and acts as a complementary tool to analytical approximations and simulations. The advantages and limitations of various codon-based models are compared, and illustrated by examples with real biological complexities such as slow codons, premature termination and feedback regulation. Our studies reveal that while different models gives broadly similiar trends in many cases, important differences also arise and can be clearly seen, in the dependence of the translation rate on different parameters. Furthermore, the update rule affects the steady state solution.
Conclusions
The codon-based models are based on different levels of abstraction. Our analysis suggests that a multiple model approach to understanding translation allows one to ascertain which aspects of the conclusions are robust with respect to the choice of modelling methodology, and when (and why) important differences may arise. This approach also allows for an optimal use of analysis tools, which is especially important when additional complexities or regulatory mechanisms are included. This approach can provide a robust platform for dissecting translation, and results in an improved predictive framework for applications in systems and synthetic biology.
hope it help friends
number 2
number 2 because the colour doesnt matter
This can cause mutations, these mutations can be helpful,harmless or they can be harmful.
The action the nurse should tell the patient is to- have the patient sit in a chair with the feet flat on the floor- when this person is newly diagnosed with stage 1 hypertension.
Hope this helps, please remember to thank me.
Cnidarians can detect and respond to stimuli equally from
all direction. The nerve nets spread radially around their body could
be a reason for such response. The correct answer between all the
choices given is the third choice or letter C. I am hoping that this answer has
satisfied your query and it will be able to help you in your endeavor, and if
you would like, feel free to ask another question.
