Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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1) carries food and oxygen to the different cells of the body; 2) carries body wastes away; 3) protects the body from diseases; and 4) serves as the body's defense system.
it is one of the transport systems of the human body that is composed of the heart, the blood and the blood vessels. Its functions include: 1) carries food and oxygen to the different cells of the body; 2) carries body wastes away; 3) protects the body from diseases; and 4) serves as the body's defense system.
Base on studies and researches and the DRI guidelines in
which had provided factual and evidence, the desirable intake of dietary fiber
among women who is under at the age of fifty years old is that they should have
twenty five grams of fiber daily.
<span>The smell of Danger.
Researchers have discovered a single compound found in high concentrations in the urine of carnivores that triggers an instinctual avoidance response in mice and rats. This is the first time that scientists have identified a chemical tag that would let rodents sense carnivores in general from a safe distance.</span>
