An example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation is option B: replacement of a polar amino acid with another polar amino acid at the protein's surface.
A frequent and well-known example of a missense mutation is the blood condition sickle-cell anemia. Missense mutations exist in the DNA at a single location in sickle-cell anemia patients. A different amino acid is required in this missense mutation, which also alters the overall structure of the protein. Similarly, replacement of a polar amino acid by another polar Ami no acid at the protein's surface is a missense mutation causing change in a single site.
A neutral mutation is one whose fixation is unrelated to natural selection. Therefore, the independence of a mutation's fixation from natural selection can be used to define the selective neutrality of a mutation.
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Complete question is:
Which example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation?
a) Replacement of a polar amino acid with a nonpolar amino acid at the protein's outer surface
b) Replacement of a polar amino acid with another polar amino acid at the protein's surface
c) Replacement of a polar amino acid with another polar amino acid in the protein's interior
d) Replacement of a polar amino acid with a nonpolar amino acid in the protein's interior
The answer is c because the genes has all the genetic information inside of it.
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Answer:
Proteinuria occurs when the filtration membrane becomes leaky, allowing proteins to cross. This impacts the blood colloid osmotic pressure by decreasing the osmolarity gradient between the blood and filtrate, thereby reducing the strength of this pressure.
Explanation:
Proteinuria is the medical term that describes the presence of proteins in the urine. <u>Proteins, in normal conditions, are not capable of filtrating through the membrane</u> but, in the presence of a disease, this is possible.
Proteins are responsible for the colloid osmotic pressure in the blood vessels, so when proteins get filtered, this pressure decreases and so does the osmolarity gradient between the blood and filtrate. <u>The decrease in osmolarity gradient also produces a decrease of the colloid osmotic pressure because the strength of the pressure is as big as the gradient between the two compartments</u>.
