Answer:
Topogenic sequences share a series of structural features, and thereby computational algorithms can be used to predict these protein-membrane segments
Explanation:
Topogenic sequences are protein segments formed by alpha-helical transmembrane domains, which are required for the insertion of membrane proteins. These domains share a series of well-defined features: they are composed of segments of about 20 hydrophobic amino-acid residues. In consequence, computational algorithms can be designed to identify protein patterns that fulfill these structural requirements (i.e. segments with a length of 20 residues, hydrophobic level, etc). The models assign a similarity threshold (threshold value) that predict if the similarity level of the protein pattern is good enough to detect a topogenic segment.
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A common birth defect characterized by an opening between the upper lip and the nose is called Cleft Lip. Cleft lip happens during the early stage of pregnancy. This occurs when there is an unsuccessful connection in the face and lip area while the fetus is developing inside the womb. Both cleft lip and cleft palate are successfully treated with surgery.
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