Question

A client with impaired liver function secondary to hepatitis c requires a centrally acting skeletal muscle relaxant for temporary pain relief. what medication would put the least metabolic burden on the client’s liver?

Answer 1

The right answers are baclofen and cyclobenzaprine (if the liver failure is not severe).

The liver does not play a major role in the metabolism of baclofen. However, it can cause an increase in liver enzymes. It should be administered with caution in patients with hepatic impairment.

Cyclobenzaprine should be used with caution in subjects with mild liver failure. Because of the lack of data, This drug should not be given to subjects with severe impairment.