As seen in the video game death stranding.
Two extinction level events happened and wiped out half of all human life. Building and cars and homes were destroyed and replaced by growling grass or dirt. A new species of bug came about called a cryptobite and a bridge was formed between the world of living and dead and hence forth came the rise of beached things
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
Answer:
C
Explanation:
As the Earth moves in relative to the moon the Earth blocks part of the sun from the moon causing only parts of the moon to light up. This BEST answers the question because B is not accurate because it doesn't describe why we actually SEE it. A might be true but it is not the BEST explained.
Hope this helps! (^-^)
<span>Since a gene that acts as a pesticide is inserted into a corn, that corn is now safe from insects. This will happen because the corn will probably synthesise protein according to that inserted DNA sequence and that protein will serve as a repellent to the insects. However, the Red Queen's hypothesis in evolution explains that organisms must constantly adapt and evolve in order to survive. This refers to insects. If they could not eat genetically modified corn, they would extinct. So, they must adapt or evolve in order to survive. So, it is expected that insects that are resistant to this specific pesticide would develop through the time.</span>
