<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
<span>Crossover is the first way that genes are shuffled to give rise to genetic diversity. Crossover takes place in sexual reproduction. Chromosomes line up side by side and break off pieces of themselves, then trade those pieces with each other. When they break at the same place (locus) in the sequence of base pairs, the result is an exchange of genes called genetic recombination. That is the normal way for crossover to occur. Genetic recombination ensures that the daughter cells produced have a different genetic makeup from the parent cell and thus diversity is created.</span>
Answer:
The correct answer would be - Cells begin dividing faster, leading to cancer.
Explanation:
In the process of the cell cycle, there are several checkpoints that ensures that the cell is all set to move to next phase, the cell that not match the requirements cell have not move to next phase.
These checkpoints control the rate of cell proliferation or division and if a dividing cell fails to pass through any checkpoints due to the mutation, it is most likely divide uncontrollably and lead to cancerous or tumor cell.
Thus, the correct answer is - Cells begin dividing faster, leading to cancer.
B. Crab
is your answer
An crab has an exoskeleton
hope this helps
~Hello there! ^_^
Your question: How often is CO2 cycled through the atmosphere?
Your answer: CO2 is cycled through the atmosphere in 350 years.
Hope this helps~
