A man who smokes one pack of cigarettes daily has been diagnosed with chronic bronchitis. He has been prescribed theophylline by
his family doctor. What effect will the patient's smoking status have on the therapeutic use of theophylline?Response Feedback: Smoking cigarettes may decrease serum theophylline levels. In fact, some patients who smoke require an increase in theophylline dosage of up to 50%. Theophylline is not associated with a risk of anaphylactoid reaction. Theophylline doses do not need to be concurrent with the use of bronchodilators
Smoking cigarettes may decrease serum theophylline levels. Intact some patients who smoke require an increase in serum theophylline dosage of up to 50%.
Explanation:
Smoking smokers on theophylline tends to require higher doses than non smokers because tobacco contains polycyclic hydrocarbons(nicotine) which induces CYPIA2 ( more rapid clearance of theophylline).
