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Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:
- The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
- Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
- Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
- Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
- Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
- Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
- The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.
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Explanation:
An inhibitor of carbonic anhydrase would interfere with oxygen binding to hemoglobin, increase blood pH due to increased H+, increase the amount of bicarbonate formed in the blood and decrease the amount of carbon dioxide dissolved in plasma.
Carbonic anhydrase catalyses the reaction between carbon dioxide and water to form carbonic acid. Carbonic acid dissociates to form hydrogen carbonate ions and hydrogen ions. The hydrogen ions combine with haemoglobin to form weak haemoglobinic acid.
Answer:
First Law of Thermodynamics in Biological Systems
All biological organisms require energy to survive. ... The chemical energy is stored in the form of glucose, which is used to form complex carbohydrates necessary to build plant mass. The energy stored in glucose can also be released through cellular respiration.
Explanation: