Answer:
Activation of infectious inflammation:
PAMPs are derived from microorganisms and thus drive inflammation in response to infections. After identifying microorganisms infections PAMPs by PRRs, activate cytoplasmic complexes called inflammasomes.
After activation of inflammasomes, these inflammasomes activate the protease caspase-1, which then cleaves or breaks various pro-inflammatory cytokines, resulting in maturation and cellular release that cause inflammatory reactions.
Answer:
"I will take three nitroglycerin tablets 5 minutes apart, and if I do not have any relief I will seek emergency care immediately."
Explanation:
sublingual nitroglycerin is prescribed to clients with stable or unstable angina to relieve chest pain symptoms.
The client is advised to take up to three tablets of sublingual nitroglycerin 5 minutes apart for relieve of chest pain and if there's no relieve to seek emergency medical care immediately.
P.S: it is advised to take few doses as necessary to relieve pain at the first sign of pain
An adaptation-----------------------
Answer:
Mutation occurred in ribosome binding site that serves as binding site for 30S ribosomal subunit of <em>E. coli</em> and allows the process of protein synthesis to begin.
Explanation:
The initiation of protein synthesis in bacteria requires binding of the ribosome to the ribosome binding site. The ribosome binding site in bacteria consists of the initiation codon "AUG" and the preceding Shine-Dalgarno sequence. The AUG initiation codon and Shine Delgrano sequence are around 10 bases apart.
The sequence is polypurine hexamer and is represented by 5' ...AGGAGG...3'. Shine-Delgrano sequence is complementary to the conserved sequence present at the 3' end of 16SrRNA of the 30S subunit of the bacterial ribosome. Binding of Shine Delgrano sequence of ribosome binding site and the complementary sequence of the 30S ribosomal subunit marks the first step in the initiation of protein synthesis.
Any mutation in the ribosome binding site would not allow the process of protein synthesis to start or would reduce the rate of the initiation of protein synthesis.
