Question

DELTA-BLAST (select all that apply): Group of answer choices does not use a position-specific scoring matrix (PSSM) in calculating a score. has the option of using PSI-BLAST iteratively following an initial search. uses a Conserved Domain Database as part of its search. is a powerful tool to look for related proteins with larger evolutionary divergence.

Answer 1

Answer: the selections are on the explanations

Explanation:

BLAST is a commonly-used software package for comparing a query sequence to a database of known sequences.

Delta blast searches a database of pre-constructed PSSMs before searching a protein-sequence database, to yield better homology detection. It first uses RPS-BLAST to align a query sequence to conserved domains in CDD. DELTA-BLAST employs a subset of NCBI's (National Center for Biotechnology Information) Conserved Domain Database (CDD), which performs a sequence database search using a PSSM derived from the aligned domains.