Why did so many American Indians die as a result of European disease? A. Europeans targeted American Indian populations. B. Amer
ican Indians lacked natural immunities to European diseases. C. The diseases spread quickly because of the climate in North America. D. The disease spread quickly as more interactions took place.
Explanation: The Democratic-Republican Party was the second political party created in the United States, having been founded in 1792 by Thomas Jefferson and his friend James Madison.